PKU is a rare genetic disease affecting children and adults. Unmanaged, it results in the buildup of phenylalanine (Phe) in the blood with a variety of very deleterious clinical complications, including cognitive decline. Patients, particularly children, must adhere to a strict diet, sometimes accompanied by supplements and medications, to maintain their Phe levels between 2 and 6 mg/dl.

Kilele Health wants to empower these patients with real-time data to manage their Phe levels, much like continuous glucose monitoring has empowered Type 1 diabetics.

PAH is a rare disease, but it is also widely believed to be underdiagnosed. This condition results in a narrowing and thickening of pulmonary arteries, and left untreated, often results in heart failure. Like heart failure, there are a number of drugs that can be potentially brought to bear.

Kilele Health wants to use real-time NT-proBNP trends to help doctors and patients optimize the timing and dosing of the medication mix to prevent the progression of PAH into heart failure.

HF results in over 4 million hospital admissions in the U.S. annually, with shockingly high 30-day readmission rates ranging from 15% to 25%. This readmissions crisis creates a $16B cost burden on hospital systems and harms long-term patient outcomes.

Kilele Health wants to use real-time NT-proBNP trends, and then add potassium and creatinine trends, to help doctors and patients accelerate the time to achieve guideline-directed medical therapy after hospital discharge, potentially cutting the readmission rate in half.

Everyone feels anxious from time to time, but over 40 million Americans are formally diagnosed with one or more anxiety disorders. While drugs have revolutionized the treatment of these disorders, much more can be done to help patients optimize the benefits of drugs as well as psychotherapy and management techniques.

Kilele Health believes real-time information on cortisol levels may prove to be key to helping patients and their care team dial in the right balance of medication(s), therapy, and management techniques to prevent escalation of anxiety and dramatically reduce progression to crisis.